| ncRNA name | KCNQ1OT1 |
| ncRNA Category | lncRNA |
| ID | 10984 |
| Ensembl | ENSG00000269821 |
| Synonyms | LIT1; Kncq1; KvDMR1; KCNQ10T1; KCNQ1-AS2; KvLQT1-AS; NCRNA00012 |
| Disease name | diabetic retinopathy (DR) |
| Species | Homo sapiens |
| Tissues/Cell_line | human retinal endothelial cells (HRECs) |
| Methods | CCK-8 assay, scratch assay, transwell assay, tube formation assay, Western blot, microarray, qRT‐PCR, flow cytometry, luciferase reporter assay |
| Expression pattern | up-regulated |
| Functional description | KCNQ1OT1 level was upregulated while microRNA-1470 (miR-1470) was decreased in DR patients and human retinal endothelial cells. KCNQ1OT1 could sponge miR-1470 and further regulate EGFR in DR. |
| PubMed ID | 30784065 |
| Year | 2019 |
| Title | KCNQ1OT1 affects the progression of diabetic retinopathy by regulating miR-1470 and epidermal growth factor receptor. |
| Drug-related ncRNA | NO |
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